Family Medicine PA
Madison Brown
"Adding this product helps to keep my blood sugar more consistent, curve off those sugar cravings, and helps me to feel more energetic throughout the day."
Review: GLP-1 Optimal
Product Highlights
- Formulated with scientifically backed ingredients
- Free from Gluten, Dairy, Soy and Sugar. Non-GMO.
- Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients
- Serving size of 2 small capsules once per day
- 60 plant-based capsules per jar
- Designed for women and men
- 90 day money back guarantee
GLP-1 Optimal
With Dihydroberberine, Yerba mate, Acacia fiber
- Made in USA, 60 Vegan Capsules
99% customers reported experiencing less food craving in the first week
- Promote GLP-1 production (hormone that regulates fullness) by 40%
- Support healthy, mindful eating
- Support reducing calorie/sugar intake
Purchase options:
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2-5 DaysFast Delivery
90-Day Money-BackGuaranteeEurofins certified/verifiedTested for heavy metals & microbes. 15 hidden weight-loss drugs screened - none detected.
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What's inside & what's not
What's inside
- DihydroBerberine (DHB)
- Yerba Mate
- Acacia Fiber
- Peppermint Extract
- Plant-based capsules
What's not
- Gluten, dairy & soy
- Sugar
- GMOs
- Synthetic GLP-1
- Hidden drugs (15 screened, none detected)
Who It's For
If you check any of these boxes, this is for you:
- You deal with nonstop food cravings
- You find yourself snacking all the time
- You’ve hit a weight-loss plateau
- Shedding pounds feels harder than it should
- You often feel bloated after meals
- You eat beyond fullness more than you’d like
- You want to feel more confident in your body
- You’d love to slip back into your favorite jeans
- Suspect you may have a blood sugar imbalance
Product Details
Holistic GLP-1 Support at Every Meal
Lasting weight balance, appetite, and eating habits are shaped by many factors. GLP-1 Optimal is crafted to be your mealtime partner, delivering comprehensive GLP-1 support for healthy eating.
- Encourages healthy appetite control*
- Helps curb cravings*
- Supports visceral fat reduction*
Results may vary. Best used alongside a balanced diet and regular exercise. GLP-1 Optimal does not contain synthetic GLP-1 and is not a substitute for GLP-1 agonist medications.
How To Use
Take 2 capsules daily with a glass of water before your heaviest meals of the day.
Precaution
- People who are sensitive to any ingredient of the product should not use it or should carefully check the ingredients before use.
- Avoid combining with other weight-loss supplements without medical advice.
- Consult your healthcare professional before use if you have a health condition or are under medical treatment.
- For more details, please check the FAQ.
90-day Money-back Guarantee
If you’re not satisfied with our products for any reason, simply request a return within 90 days.
Trusted By Our Happy Customers
Real customer-reported results from using Wellio’s products
Addison
"Late at night, I crave snacks, but since I take Wellio, I notice fewer cravings and feel more control."
Review: GLP-1 Optimal
Medical Doctor | Health Coach
Bryan J Treacy
“I feel satisfied longer after meals, and my energy stayed steady. Plus, my digestion felt smoother and more comfortable.”
Review: GLP-1 Optimal
Jada
"Thanks to Wellio GLP-1 Optimal, I can finally look confident in my body."
Review: GLP-1 Optimal
Destine
"After just a few days, I notice my usual snack cravings way less intense."
Review: GLP-1 Optimal
Erika
"I'm more satisfied after having my 3 main meals, and I don't reach snacks like I used to."
Review: GLP-1 Optimal
Jessica
"I finally feel in control, my cravings no longer haunt me! It's help my body turn down the hunger noise and give me that willpower boost that I've been needing."
Review: GLP-1 Optimal
Real results,
in their words
↓ 21 lbs in 4 months
Meet Jessica
"I tried counting every calorie. It always felt like a battle, and I’d burn out. This time, I didn’t have to force it. I actually feel proud when I look in the mirror."
↓ 16 lbs in 6 months
Meet Natalie
"I was so self-conscious I didn’t even want to go out or take pictures. Losing weight with GLP-1 helped me feel like myself again."
↓ 8 lbs in 5 months
Meet Alicia
"Love it! I used to eat from stress, especially after bad days. I’d tried detoxes and gym routines, but nothing stuck. This time it felt totally different!"
↓ 18 lbs in 3 months
Meet Haley
"I used to think losing weight meant being hungry all the time. But for the first time, it didn’t feel like a fight. I just ate less naturally."
They Did It.
So Can You!
Real people broke free from constant cravings and the exhausting fight of relying only on self-control.
Their stories can be your starting point.
The Benefits
Reduce Food Cravings*
Helps quiet cravings by naturally increasing GLP-1 levels and supporting appetite regulation.
Free from Food Guilt*
Promotes healthier eating habits without the stress or guilt.
Support GLP-1 Production*
Support the body’s own production of GLP-1 - a gut hormone that regulates fullness.
Support Visceral Fat Reduction*
Supports metabolic function and helps maintain a healthy fat balance.
What To Expect
Cancel food noise, enhance energy and support healthy weight management
Week 1–2
Less Hunger*
You feel full for longer period of time after each meal.
Week 4
Quiet Food Noise*
As your GLP-1 level goes up, you stop feeling head hunger and healthy choices are much easier.
Week 12
Sustainable Weight Management*
You start to see visible changes, fat loss and energy enhanced.
*Each individual’s experience may vary based on unique health conditions, lifestyle, and adherence to recommended use.
How This Works
Boost Natural GLP-1 Production
Activates the GCG gene to stimulate your body's own GLP-1 production in L-cells, supporting appetite regulation and blood sugar control from within.
Enhance GLP-1 Activity & Signaling
Activates GLP-1 receptors in the brain and reduces visceral fat, a major blocker of GLP-1 signaling, helping restore a healthy gut-brain connection.
Protect & Sustain GLP-1 Function
Prevents GLP-1 breakdown by providing an ideal gut environment for GLP-1 by added fiber. The fiber also keeps you feeling full longer.
Science-backed, Traceable Ingredients
DihydroBerberine (DHB)
Boost natural GLP-1 production
DHB promotes natural GLP-1 production of your body. As a more absorbable form of berberine, DHB minimizes digestive side effects, making it more effective and gut-friendly.
Country of origin: China
Yerba Mate
Enhance GLP-1 effects
Yerba mate stimulates the signaling of existing GLP-1, amplifies its effect, boosts overall metabolic function and supports the body’s natural fat breakdown, offering an energizing approach to weight management.
Country of origin: Brazil
Acacia Fiber
Protect GLP-1 from degradation
Acacia fiber provides the optimal environment for GLP-1, protecting it from degradation. By supporting metabolism, it helps increasing calorie burn and energy levels, making it a natural aid for weight management.
Country of origin: France
Peppermint Extract
Soothe the stomach
Peppermint extract helps soothe the digestive tract by relaxing the muscles of the gastrointestinal system, promoting smoother digestion. It also helps relieve bloating and discomfort, making it a gentle support for gut balance and overall digestive comfort.
Country of origin: China
Proven by Science
DihydroBerberine (DHB)
Boost natural GLP-1 production
Human cell NCI-H716 that received 100 mM of Berberine showed around 40% increase in GLP-1 levels, rising from 0.34 pM/mg protein to 0.51 pM/mg protein after 5 weeks.
Modulation of glucagon-like peptide-1 release by berberine: In vivo and invitro studies. Yunli Yu, Li Liu, Xinting Wang, Xiang Liu, Xiaodong Liu *, Lin Xie, Guangji Wang. November 2009, Biochemical Pharmacology 79(7):1000-6, DOI:10.1016/j.bcp.2009.11.017
Yerba Mate
Enhance GLP-1 effects
Yerba Mate was shown to reduce food intake by 15% within 3 weeks.
Andersen, T., Fogh, J., Düring, P., & Jensen, C. B. (2011). Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: Involvement of glucagon-like peptide-1. Obesity Research.
Acacia Fiber
Protect GLP-1 from degradation
Participants also experienced a 2.18% reduction in body fat percentage. BMI levels dropped significantly by 0.32 points after 6 weeks of daily supplementation of Acacia Fiber.
Reimer, R. A., & McBurney, M. I. (2001). Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology, 142(7), 2928–2934.
More Clinical Studies Behind Our Formula
- Modulation of glucagon-like peptide-1 release by berberine: In vivo and invitro studies
- Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: Involvement of glucagon-like peptide-1
- Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats
- Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice
- The effect of berberine supplementation on obesity indices:A dose– response meta-analysis and systematic review of randomized controlled trials
- The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity
- Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats
Our Advantages
GLP-1 Optimal
- Clinically Effective Dosage
- Stimulates Natural Production
- GLP-1 Protection
- High Bioavailability
- Safe for Long-term Use
- No Harsh Side Effects
- Vegan, Gluten Free
Generic Products
- Ingredients Dosed At Incorrect Amounts
- Short-term Results
- Degraded GLP-1
- Contain Fillers The Body Cannot Handle
- Ingredients Not Backed By Research Studies
- Side Effects Restricting Long-term Use
- May Not Be Plant-based
Your purchase is protected by our
90-day Money-back Guarantee
At Wellio, we want you to feel great about your purchase. We believe in the power of our formula so much, we're happy to take the risk so you don’t have to.
Free shipping on subscription
No one likes paying for shipping. That's why when you subscribe to any of Wellio monthly plans, we take care of the shipping for you.
90-day money-back guarantee
Most people start noticing results within the first 2 weeks, some sooner, some a little later, and that’s totally normal. The best way to find out? Give it a try! And if you’re not satisfied for any reason, simply request a refund.
Instant refunds
We want you to feel real results with our products. If it’s not the right fit for you, we’ll make it right with a quick and easy refund.
Why Choose
GLP-1 Optimal?
Absorption
Powered by dihydroberberine for superior absorption and faster effect.
Tolerance
Formulated to be gentle on the gut with minimal side effects.
Natural
Supports your body’s own GLP-1 production - no injections needed.
Proven
Backed by clinical data and built on science, not hype.
Quality
Made with top-tier, bioavailable ingredients - nothing unnecessary.
Sustainability
Designed for long-term balance, with benefits that continue even after stopping.
Question?
We gladly answer them
What is GLP-1 OPTIMAL?
GLP-1 OPTIMAL is a dietary supplement designed to naturally support the production of GLP-1, a hormone known for reducing appetite and regulating blood sugar. It offers an innovative, effective, and healthy solution to promote sustainable weight loss.
GLP-1 (Glucagon-Like Peptide-1) is a hormone secreted by L-cells, mainly in the intestine, which:
• acts on the brain to promote satiety, reduce hunger, and help control calorie intake and body weight;
• increases insulin release to regulate blood sugar when it becomes too high;
• reduces glucagon secretion to limit glucose production;
• and slows gastric emptying (the passage of food from the stomach to the small intestine) to prevent blood sugar spikes.
The role of this hormone in appetite regulation makes it a key component of weight-loss therapies. Moreover, reduced GLP-1 levels are frequently observed in people with type 2 diabetes.
Who is GLP-1 OPTIMAL recommended for?
We recommend the GLP-1 OPTIMAL for individuals who:
• Have difficulty resisting sweet snacks
• Struggle with cravings
• Feel dependent on sugar
• Suspect they may have a blood sugar imbalance
• Wish to support natural weight loss
How does GLP-1 OPTIMAL work?
Made without hormones or synthetic ingredients, GLP-1 OPTIMAL naturally stimulates the release of the GLP-1 hormone. It slows down carbohydrate digestion and helps prevent blood sugar spikes. This enhances the feeling of fullness and leads to a lower calorie intake than usual.
How to take GLP-1 OPTIMAL?
We recommend taking 2 capsules GLP-1 OPTIMAL with a glass of water before your heaviest meal of the day. The timing can depend on your eating habits and when you tend to feel the hungriest. For best results, take the capsules before your largest meal or at the time of day when appetite control is most challenging. Balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness.
How soon are the first results visible?
Results may vary from person to person. Some individuals feel a boost in energy within a few days, while weight loss effects may appear after several weeks, especially when combined with a balanced diet and a healthy lifestyle.
How long should I take GLP-1 OPTIMAL?
We recommend taking our products consistently for at least 3 months to support long-term, sustainable results.
Do I need to follow a diet while taking Wellio supplements?
No strict diet is required. However, balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness.
Are there any side effects?
GLP-1 OPTIMAL is formulated with natural ingredients (dihydroberberine, acacia fiber, yerba mate, and peppermint leaf) encapsulated in a vegan-friendly shell. These components are generally well tolerated by most users and have a long history of use in nutritional supplements.
However, individual sensitivities can vary. Some people may experience mild gastrointestinal discomfort, such as nausea, bloating, gas, or diarrhea, particularly when introducing new active ingredients or fibers into their routine. These effects are usually temporary and often related to the body’s adjustment period. Starting with a lower dose and gradually increasing to the recommended amount may help minimize these symptoms.
If any discomfort persists, worsens, or if you have existing medical conditions or concerns, it is advisable to consult your healthcare professional for personalized guidance
What safety precautions should be observed while taking a GLP-1 OPTIMAL?
WARNING
- For adults only. Do not take on an empty stomach.
- Not for use by pregnant or nursing women.
- Not recommended for individuals with diabetes, liver or heart conditions, known allergies, or those taking medications.
- Keep out of reach of children.
- Store in a cool, dry place, away from heat, moisture, and light.
What supplements should you avoid while taking GLP-1 OPTIMAL?
You should avoid taking other weight-loss supplements alongside GLP-1 OPTIMAL without medical advice. This includes :
• Blood sugar–lowering supplements which can additive-lower blood sugar and increase the risk of hypoglycemia, especially if combined with other diabetes medications.
• Stimulant or appetite-suppressant supplements. GLP-1 OPTIMAL already reduce appetite, stacking stimulants can cause nausea, heart palpitations, or excess weight loss.
• Supplements that may irritate the gut. Because GLP-1 OPTIMAL can cause nausea, bloating, or diarrhea, avoid gut-irritating products, especially at high doses.
Can I take multiple Wellio products together?
Yes! We recommend combining GLP-1 Optimal or Akkermansia Support with our Fiber Gummy for enhanced gut and metabolic health. They’re designed to work synergistically.
Can I take GLP-1 OPTIMAL with other medications?
If you are undergoing medical treatment or have a health condition, consult your healthcare professional before adding a supplement like GLP-1 OPTIMAL to your routine.
Are there any medications you shouldn’t take this with or while on GLP-1 OPTIMAL ?
The biggest risks are with other diabetes medications, drugs that must be absorbed at a specific rate, or additional weight-loss agents. Always give your doctor or pharmacist a full list of prescriptions, supplements, and over-the-counters so they can check for interactions.