GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1-06
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal

Product Highlights

Formulated with scientifically backed ingredients

Free from Gluten, Dairy, Soy and Sugar. Non-GMO.

Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients

Serving size of 2 small capsules once per day

60 plant-based capsules per jar

Designed for women and men

60 day money back guarantee

586 reviews

GLP-1 Optimal

With Dihydroberberine, Yerba mate, Acacia fiber

- Made in USA, 60 Vegan Capsules

99% customers reported experiencing less food craving in the first week

Promote GLP-1 production (hormone that regulates fullness) by 40%

Support healthy, mindful eating

Support reducing calorie/sugar intake

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Who It's For

If you check any of these boxes, this is for you:

You deal with nonstop food cravings

You find yourself snacking all the time

You’ve hit a weight-loss plateau

Shedding pounds feels harder than it should

You often feel bloated after meals

You eat beyond fullness more than you’d like

You want to feel more confident in your body

You’d love to slip back into your favorite jeans

Suspect you may have a blood sugar imbalance

Product Details

Holistic GLP-1 Support at Every Meal
Lasting weight balance, appetite, and eating habits are shaped by many factors. GLP-1 Optimal is crafted to be your mealtime partner, delivering comprehensive GLP-1 support for healthy eating.

- Encourages healthy appetite control*

- Helps curb cravings*

- Supports visceral fat reduction*

Results may vary. Best used alongside a balanced diet and regular exercise. GLP-1 Optimal does not contain synthetic GLP-1 and is not a substitute for GLP-1 agonist medications.

How To Use

Take 2 capsules daily with a glass of water before your heaviest meals of the day.

Precaution

  • People who are sensitive to any ingredient of the product should not use it or should carefully check the ingredients before use.
  • Avoid combining with other weight-loss supplements without medical advice. 
  • Consult your healthcare professional before use if you have a health condition or are under medical treatment.
  • For more details, please check the FAQ.

60-day Money-back Guarantee

If you’re not satisfied with our products for any reason, simply request a return within 60 days.

Product Highlights

Formulated with scientifically backed ingredients

Free from Gluten, Dairy, Soy and Sugar. Non-GMO.

Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients

Serving size of 2 small capsules once per day

60 plant-based capsules per jar

Designed for women and men of ALL ages

60 day money back guarantee

Trusted By Our Happy Customers

Real customer-reported results from using Wellio’s products

They Did It. 
So Can You!

Real people broke free from constant cravings and the exhausting fight of relying only on self-control.

Their stories can be your starting point.

The Benefits

Reduce Food Cravings*

Helps quiet cravings by naturally increasing GLP-1 levels and supporting appetite regulation.
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Support GLP-1 Production*

Support the body’s own production of GLP-1 - a gut hormone that regulates fullness.
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Free from Food Guilt*

Promotes healthier eating habits without the stress or guilt.
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Support Visceral Fat Reduction*

Supports metabolic function and helps maintain a healthy fat balance.
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Reduce Food Cravings*

Helps quiet cravings by naturally increasing GLP-1 levels and supporting appetite regulation.
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Free from Food Guilt*

Promotes healthier eating habits without the stress or guilt.
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Support GLP-1 Production*

Support the body’s own production of GLP-1 - a gut hormone that regulates fullness.
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Support Visceral Fat Reduction*

Supports metabolic function and helps maintain a healthy fat balance.
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Customer Reviews

Based on 114 reviews
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EP

A more effective alternative to standard berberine
When I first opened the bottle, the capsules looked clean and well-made, which gave me a good impression right away. The serving size is straightforward - two capsules daily - so it’s easy to add into a routine without much effort. What stood out to me is the use of dihydroberberine at 400mg, which is known to be more bioavailable than standard berberine. It’s paired with prebiotics, which makes sense since gut health plays a big role in how well supplements work.

Taking it consistently feels simple - no weird aftertaste and no stomach upset, which can sometimes happen with stronger metabolic supplements. Compared to regular berberine products I’ve tried, this seems to be gentler on digestion while still giving steady energy and appetite control. It’s not a quick-fix pill, but after about two weeks I noticed I felt more balanced after meals and less of that sluggish crash.

The price is a bit higher than standard berberine, but given the upgraded form and added prebiotics, I think it justifies the cost for people serious about metabolic support.

Pros: well-dosed dihydroberberine, includes prebiotics, easy to take, no stomach irritation.
Cons: only a one-month supply per bottle, results take time and consistency.

Overall, this feels best suited for someone who wants a more effective alternative to standard berberine, especially if they’re focused on managing energy, metabolism, and appetite in a natural way.

J
Jeff

This product is impressive. It is made in the USA which makes me feel confident that I'm getting something that is safe from chemicals that should not be in products. Being from the United States means that it was tested here and I can be confident in the results. This bottle arrived sealed on the top of the cap as well as under the cap. There are no funny tastes or smells. By taking this product, I feel less hungry and I have some more energy. The bottle contains 60 capsules with a recommended dosage of two capsules per day. So you are getting good value here with a 30-day supply. The capsules are not too large which makes them easy to swallow.

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Brenda

It works! Love it! Helps to prolong the GLP-1 effects to decrease cravings throughout the week. It has been a game changer while on a GLP-1 journey!

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Brenda

Solid supplement option for those looking for natural metabolic support
I recently tried Wellio GLP‑1 Optimal and I like it so far. It features 300 mg of dihydroberberine plus prebiotics and supports metabolic health and boosts natural GLP‑1 levels.

What I liked:
-Easy to take
-Gentle on digestion
-I’ve experienced a small uptick in energy and better digestion since starting

I think it's a solid supplement option for those looking for natural metabolic support. If you’re already eating well and exercising, this might give you a helpful boost!

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Erika Rodriguez

A game changer for all working professionals
I have been using Wellio’s products for a while now and i was so excited when i found out a new one came out. I am a busy working mom and trying to eat healthy or cut back on snacking at work can be a challenge. But i have been using this product and i have noticed a big difference in my appetite and my energy levels have improved tremendously. I highly recommend this product to anyone needing an extra boost of energy, help with digestive, and aid in weight loss.

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What To Expect

Cancel food noise, enhance energy and support healthy weight management

Week 1–2

Less Hunger*

You feel full for longer period of time after each meal.

Week 4

Quiet Food Noise*

As your GLP-1 level goes up, you stop feeling head hunger and healthy choices are much easier.

Week 12

Sustainable Weight Management*

You start to see visible changes, fat loss and energy enhanced.

*Each individual’s experience may vary based on unique health conditions, lifestyle, and adherence to recommended use.

How This Works

Boost Natural GLP-1 Production

Activates the GCG gene to stimulate your body's own GLP-1 production in L-cells, supporting appetite regulation and blood sugar control from within.

Enhance GLP-1 Activity & Signaling

Activates GLP-1 receptors in the brain and reduces visceral fat, a major blocker of GLP-1 signaling, helping restore a healthy gut-brain connection.

Protect & Sustain GLP-1 Function

Prevents GLP-1 breakdown by providing an ideal gut environment for GLP-1 by added fiber. The fiber also keeps you feeling full longer.

Science-backed, Traceable Ingredients

DihydroBerberine (DHB)

Boost natural GLP-1 production

DHB promotes natural GLP-1 production of your body. As a more absorbable form of berberine, DHB minimizes digestive side effects, making it more effective and gut-friendly.

Country of origin: China

Yerba Mate 

Enhance GLP-1 effects

Yerba mate stimulates the signaling of existing GLP-1, amplifies its effect, boosts overall metabolic function and supports the body’s natural fat breakdown, offering an energizing approach to weight management.

Country of origin: Brazil

Acacia Fiber

Protect GLP-1 from degradation

Acacia fiber provides the optimal environment for GLP-1, protecting it from degradation. By supporting metabolism, it helps increasing calorie burn and energy levels, making it a natural aid for weight management.

Country of origin: France

Peppermint Extract

Soothe the stomach

Peppermint extract helps soothe the digestive tract by relaxing the muscles of the gastrointestinal system, promoting smoother digestion. It also helps relieve bloating and discomfort, making it a gentle support for gut balance and overall digestive comfort.

Country of origin: China

Research-backed ingredients 

featured in

Research-backed ingredients 

featured in

Proven by Science

  • DHB

  • Yerba Mate

  • Acacia Fiber

DihydroBerberine (DHB)

Boost natural GLP-1 production

Human cell NCI-H716 that received 100 mM of Berberine showed around  40% increase in GLP-1 levels, rising from 0.34 pM/mg protein to 0.51 pM/mg protein after 5 weeks.

Modulation of glucagon-like peptide-1 release by berberine: In vivo and invitro studies. Yunli Yu, Li Liu, Xinting Wang, Xiang Liu, Xiaodong Liu *, Lin Xie, Guangji Wang. November 2009,  Biochemical Pharmacology 79(7):1000-6,  DOI:10.1016/j.bcp.2009.11.017

Yerba Mate

Enhance GLP-1 effects

Yerba Mate was shown to reduce food intake by 15% within 3 weeks.

Andersen, T., Fogh, J., Düring, P., & Jensen, C. B. (2011). Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: Involvement of glucagon-like peptide-1. Obesity Research. Retrieved from https://www.researchgate.net/publication/51842833_Mate_Tea_Ilex_paraguariensis_Promotes_Satiety_and_Body_Weight_Lowering_in_Mice_Involvement_of_Glucagon-Like_Peptide-1

Acacia Fiber

Protect GLP-1 from degradation

Participants also experienced a 2.18% reduction in body fat percentage. BMI levels dropped significantly by 0.32 points after 6 weeks of daily supplementation of Acacia Fiber.

Reimer, R. A., & McBurney, M. I. (2001). Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology, 142(7), 2928–2934.

More Clinical Studies Behind Our Formula

Modulation of glucagon-like peptide-1 release by berberine: In vivo and invitro studies

Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: Involvement of glucagon-like peptide-1

Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats

Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice

The effect of berberine supplementation on obesity indices:A dose– response meta-analysis and systematic review of randomized controlled trials

The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity

Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats

Our Advantages

GLP-1 Optimal

Clinically Effective Dosage

Stimulates Natural Production

GLP-1 Protection

High Bioavailability

Safe for Long-term Use

No Harsh Side Effects

Vegan, Gluten Free

Generic Products

Ingredients Dosed At Incorrect Amounts

Short-term Results

Degraded GLP-1

Contain Fillers The Body Cannot Handle

Ingredients Not Backed By Research Studies

Side Effects Restricting Long-term Use

May Not Be Plant-based

Your purchase is protected by our

60-day Money-back Guarantee

At Wellio, we want you to feel great about your purchase. We believe in the power of our formula so much, we're happy to take the risk so you don’t have to.

Free shipping on subscription

No one likes paying for shipping. That's why when you subscribe to any of Wellio monthly plans, we take care of the shipping for you.

60-day money-back guarantee

Most people start noticing results within the first 2 weeks, some sooner, some a little later, and that’s totally normal. The best way to find out? Give it a try! And if you’re not satisfied for any reason, simply request a refund.

Instant refunds

We want you to feel real results with our products. If it’s not the right fit for you, we’ll make it right with a quick and easy refund.

Why Choose 
GLP-1 Optimal?

Absorption

Powered by dihydroberberine for superior absorption and faster effect.

Tolerance

Formulated to be gentle on the gut with minimal side effects.

Natural

Supports your body’s own GLP-1 production - no injections needed.

Proven

Backed by clinical data and built on science, not hype.

Quality

Made with top-tier, bioavailable

ingredients - nothing unnecessary.

Sustainability

 Designed for long-term balance, with benefits that continue even after stopping.

Question?

We gladly answer them

What is GLP-1 OPTIMAL?

GLP-1 OPTIMAL is a dietary supplement designed to naturally support the production of GLP-1, a hormone known for reducing appetite and regulating blood sugar. It offers an innovative, effective, and healthy solution to promote sustainable weight loss.
GLP-1 (Glucagon-Like Peptide-1) is a hormone secreted by L-cells, mainly in the intestine, which:
•        acts on the brain to promote satiety, reduce hunger, and help control calorie intake and body weight;
•        increases insulin release to regulate blood sugar when it becomes too high;
•        reduces glucagon secretion to limit glucose production;
•        and slows gastric emptying (the passage of food from the stomach to the small intestine) to prevent blood sugar spikes.
The role of this hormone in appetite regulation makes it a key component of weight-loss therapies. Moreover, reduced GLP-1 levels are frequently observed in people with type 2 diabetes.

Who is GLP-1 OPTIMAL recommended for?

We recommend the GLP-1 OPTIMAL for individuals who:
•        Have difficulty resisting sweet snacks
•        Struggle with cravings
•        Feel dependent on sugar
•        Suspect they may have a blood sugar imbalance
•        Wish to support natural weight loss

How does GLP-1 OPTIMAL work?

Made without hormones or synthetic ingredients, GLP-1 OPTIMAL naturally stimulates the release of the GLP-1 hormone. It slows down carbohydrate digestion and helps prevent blood sugar spikes. This enhances the feeling of fullness and leads to a lower calorie intake than usual.

How to take GLP-1 OPTIMAL?

We recommend taking 2 capsules  GLP-1 OPTIMAL with a glass of water before your heaviest meal of the day. The timing can depend on your eating habits and when you tend to feel the hungriest. For best results, take the capsules before your largest meal or at the time of day when appetite control is most challenging. Balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness. 

How soon are the first results visible?

Results may vary from person to person. Some individuals feel a boost in energy within a few days, while weight loss effects may appear after several weeks, especially when combined with a balanced diet and a healthy lifestyle.

How long should I take GLP-1 OPTIMAL?

We recommend taking our products consistently for at least 3 months to support long-term, sustainable results.

Do I need to follow a diet while taking Wellio supplements?

No strict diet is required. However, balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness. 

Are there any side effects?

GLP-1 OPTIMAL is formulated with natural ingredients (dihydroberberine, acacia fiber, yerba mate, and peppermint leaf) encapsulated in a vegan-friendly shell. These components are generally well tolerated by most users and have a long history of use in nutritional supplements. 

However, individual sensitivities can vary. Some people may experience mild gastrointestinal discomfort, such as nausea, bloating, gas, or diarrhea, particularly when introducing new active ingredients or fibers into their routine. These effects are usually temporary and often related to the body’s adjustment period. Starting with a lower dose and gradually increasing to the recommended amount may help minimize these symptoms. 

If any discomfort persists, worsens, or if you have existing medical conditions or concerns, it is advisable to consult your healthcare professional for personalized guidance

What safety precautions should be observed while taking a GLP-1 OPTIMAL?

WARNING

  • For adults only. Do not take on an empty stomach.
  • Not for use by pregnant or nursing women.
  • Not recommended for individuals with diabetes, liver or heart conditions, known allergies, or those taking medications.
  • Keep out of reach of children.
  • Store in a cool, dry place, away from heat, moisture, and light.

What supplements should you avoid while taking GLP-1 OPTIMAL?

You should avoid taking other weight-loss supplements alongside GLP-1 OPTIMAL without medical advice. This includes : 
•        Blood sugar–lowering supplements which can additive-lower blood sugar and increase the risk of hypoglycemia, especially if combined with other diabetes medications.
•        Stimulant or appetite-suppressant supplements. GLP-1 OPTIMAL already reduce appetite, stacking stimulants can cause nausea, heart palpitations, or excess weight loss.
•        Supplements that may irritate the gut. Because GLP-1 OPTIMAL can cause nausea, bloating, or diarrhea, avoid gut-irritating products, especially at high doses.

Can I take multiple Wellio products together?

Yes! We recommend combining GLP-1 Optimal or Akkermansia Support with our Fiber Gummy for enhanced gut and metabolic health. They’re designed to work synergistically.

Can I take GLP-1 OPTIMAL with other medications?

If you are undergoing medical treatment or have a health condition, consult your healthcare professional before adding a supplement like GLP-1 OPTIMAL to your routine.

Are there any medications you shouldn’t take this with or while on GLP-1 OPTIMAL ?

The biggest risks are with other diabetes medications, drugs that must be absorbed at a specific rate, or additional weight-loss agents. Always give your doctor or pharmacist a full list of prescriptions, supplements, and over-the-counters so they can check for interactions.
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1-06
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal

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