GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal

With Dihydroberberine, Yerba mate, Prebiotics Acacia fiber

- Made in USA, 60 Vegan Capsules

Promote GLP-1 production (hormone that regulates fullness) by 40%*

Reduce food intake by 15% in 3 weeks*

Support healthy, mindful eating*

Support reducing calorie/sugar intake*

Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients. Free from Gluten, Dairy, Soy and Sugar. Non-GMO.

586 reviews

GLP-1 Optimal

92% customers reported experiencing less food craving in the first week*

Curbs cravings

Burns fat

Safe for long-term

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Who It's For

If you check any of these boxes, this is for you:

You deal with nonstop food cravings

You find yourself snacking all the time

You’ve hit a weight-loss plateau

Shedding pounds feels harder than it should

You often feel bloated after meals

You eat beyond fullness more than you’d like

You want to feel more confident in your body

You’d love to slip back into your favorite jeans

Suspect you may have a blood sugar imbalance

Product Details

Holistic GLP-1 Support at Every Meal
Lasting weight balance, appetite, and eating habits are shaped by many factors. GLP-1 Optimal is crafted to be your mealtime partner, delivering comprehensive GLP-1 support for healthy eating.

- Encourages healthy appetite control*

- Helps curb cravings*

- Supports visceral fat reduction*

Results may vary. Best used alongside a balanced diet and regular exercise. GLP-1 Optimal does not contain synthetic GLP-1 and is not a substitute for GLP-1 agonist medications.

How To Use

Start low – go slow
You may experience mild digestive changes like nausea, bloating, or diarrhea - these are typically due to increased activity in the gut as your body adjusts to Dihydroberberine. These effects are usually temporary.
Day 1-7
Take 1 capsule (150mg) daily with a glass of water before your meal.
Day 8+
If tolerated, increase to 2 capsules (300 mg) daily, split into morning and evening with a glass of water before your heaviest meal of the day.

Precaution

  • People who are sensitive to any ingredient of the product should not use it or should carefully check the ingredients before use.
  • Avoid combining with other weight-loss supplements without medical advice. 
  • Consult your healthcare professional before use if you have a health condition or are under medical treatment.
  • For more details, please check the FAQ.

60-day Money-back Guarantee

If you’re not satisfied with our products for any reason, simply request a return within 60 days.
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Product Highlights

Formulated with scientifically backed ingredients

Free from Gluten, Dairy, Soy and Sugar. Non-GMO.

Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients

Serving size of 2 small capsules once per day

60 plant-based capsules per jar

Designed for women and men of ALL ages

60 day money back guarantee

With Dihydroberberine, Yerba mate, Prebiotics Acacia fiber - Made in USA, 60 Vegan Capsules

Promote GLP-1 production (hormone that regulates fullness) by 40%*

Reduce food intake by 15% in 3 weeks*

Support healthy, mindful eating*

Support reducing calorie/sugar intake*

Made in a FDA-Registered, GMP-Certified Facility with the finest local and globally sourced ingredients. Free from Gluten, Dairy, Soy and Sugar. Non-GMO.

Trusted By Our Happy Customers

Real customer-reported results from using Wellio’s products

They Did It. 
So Can You!

Real people broke free from constant cravings and the exhausting fight of relying only on self-control.

Their stories can be your starting point.

Explore More

Formulated for Lasting Results

Formulated with clinically researched ingredients, GLP-1 Optimal helps you achieve weight loss that lasts so you can feel your best, without the burden of restrictive dieting

Reduce Food Cravings*
 

15% reduced in food intake

Helps quiet cravings by naturally increasing GLP-1 levels and supporting appetite regulation.

Support GLP-1 Production*

 

40% increased in GLP-1 production

Support the body’s own production of GLP-1 - a gut hormone that regulates fullness.

Burn Stubborn Visceral Fat*

 

2.18% decreased in body fat

Supports metabolic function and helps maintain a healthy fat balance.

Keep Weight Off Long Term*

 

Maintain healthy weight loss

Addressing the root cause of weight gain to help you maintain your result long term.

How GLP-1 Optimal Works

GLP-1 is a key hormone that naturally supports healthy metabolism and appetite

Boost Natural GLP-1 Production

Activates the GCG gene to stimulate your body's own GLP-1 production in L-cells, supporting appetite regulation and blood sugar control from within.

Enhance GLP-1 Activity & Signaling

Activates GLP-1 receptors in the brain and reduces visceral fat, a major blocker of GLP-1 signaling, helping restore a healthy gut-brain connection.

Protect & Sustain GLP-1 Function

Prevents GLP-1 breakdown by providing an ideal gut environment for GLP-1 by added fiber. The fiber also keeps you feeling full longer.

What To Expect

Cancel food noise, enhance energy and support healthy weight management

Week 1–2

Less Hunger*

You feel full for longer period of time after each meal.

Week 4

Quiet Food Noise*

As your GLP-1 level goes up, you stop feeling head hunger and healthy choices are much easier.

Week 12

Sustainable Weight Management*

You start to see visible changes, fat loss and energy enhanced.

*Each individual’s experience may vary based on unique health conditions, lifestyle, and adherence to recommended use.

Proven By Science

  • DHB

  • Yerba Mate

  • Acacia Fiber

DihydroBerberine (DHB)

Boost natural GLP-1 production

Human cell NCI-H716 that received 100 mM of Berberine showed around 40% increase in GLP-1 levels after 5 weeks.

Modulation of glucagon-like peptide-1 release by berberine: In vivo and invitro studies. Yunli Yu, Li Liu, Xinting Wang, Xiang Liu, Xiaodong Liu *, Lin Xie, Guangji Wang. November 2009,  Biochemical Pharmacology 79(7):1000-6,  DOI:10.1016/j.bcp.2009.11.017

Yerba Mate

Enhance GLP-1 effects

Yerba Mate was shown to reduce food intake by 15% within 3 weeks.

Andersen, T., Fogh, J., Düring, P., & Jensen, C. B. (2011). Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: Involvement of glucagon-like peptide-1. Obesity Research. Retrieved from https://www.researchgate.net/publication/51842833_Mate_Tea_Ilex_paraguariensis_Promotes_Satiety_and_Body_Weight_Lowering_in_Mice_Involvement_of_Glucagon-Like_Peptide-1

Acacia Fiber

Protect GLP-1 from degradation

Participants experienced a 2.18% reduction in body fat and a 0.32 points reduction in BMI levels after 6 weeks of daily supplementation of Acacia Fiber.

Reimer, R. A., & McBurney, M. I. (2001). Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology, 142(7), 2928–2934.

Our Advantages

Wellio

GLP-1 Medications

Boost natural 

GLP-1

Reduces cravings long-term

No injectables

Promotes healthy eating habit

Easy to maintain over time

No harsh side effects

Wellio

GLP-1 Medications

Other GLP-1 Supplements

Boost natural GLP-1

Reduces cravings long-term

Start working within the first week

Promotes healthy eating habit

Easy to maintain over time

No injectables

From Our Customers

Recommended By Experts

"Five times more absorbable making it more effective. I like to think GLP-1 Optimal upgraded berberine from a flip phone to a smart phone."

Family Medicine PA

Madison Brown

"Compared to other products, this is an affordable way to stimulate your GLP-1 naturally everyday."

Medical Doctor | Health Coach

Bryan J Treacy

Question?

We gladly answer them

What is GLP-1 OPTIMAL?

GLP-1 OPTIMAL is a dietary supplement designed to naturally support the production of GLP-1, a hormone known for reducing appetite and regulating blood sugar. It offers an innovative, effective, and healthy solution to promote sustainable weight loss.
GLP-1 (Glucagon-Like Peptide-1) is a hormone secreted by L-cells, mainly in the intestine, which:
•        acts on the brain to promote satiety, reduce hunger, and help control calorie intake and body weight;
•        increases insulin release to regulate blood sugar when it becomes too high;
•        reduces glucagon secretion to limit glucose production;
•        and slows gastric emptying (the passage of food from the stomach to the small intestine) to prevent blood sugar spikes.
The role of this hormone in appetite regulation makes it a key component of weight-loss therapies. Moreover, reduced GLP-1 levels are frequently observed in people with type 2 diabetes.

Who is GLP-1 OPTIMAL recommended for?

We recommend the GLP-1 OPTIMAL for individuals who:
•        Have difficulty resisting sweet snacks
•        Struggle with cravings
•        Feel dependent on sugar
•        Suspect they may have a blood sugar imbalance
•        Wish to support natural weight loss

How does GLP-1 OPTIMAL work?

Made without hormones or synthetic ingredients, GLP-1 OPTIMAL naturally stimulates the release of the GLP-1 hormone. It slows down carbohydrate digestion and helps prevent blood sugar spikes. This enhances the feeling of fullness and leads to a lower calorie intake than usual.

How to take GLP-1 OPTIMAL?

We recommend taking 2 capsules  GLP-1 OPTIMAL with a glass of water before your heaviest meal of the day. The timing can depend on your eating habits and when you tend to feel the hungriest. For best results, take the capsules before your largest meal or at the time of day when appetite control is most challenging. Balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness. 

How soon are the first results visible?

Results may vary from person to person. Some individuals feel a boost in energy within a few days, while weight loss effects may appear after several weeks, especially when combined with a balanced diet and a healthy lifestyle.

How long should I take GLP-1 OPTIMAL?

We recommend taking our products consistently for at least 3 months to support long-term, sustainable results.

Do I need to follow a diet while taking Wellio supplements?

No strict diet is required. However, balanced diet and regular physical activity will enhance the beneficial effects of GLP-1 OPTIMAL your overall wellness. 

Are there any side effects?

GLP-1 OPTIMAL is made with natural ingredients and is well tolerated by most users. However, sensitivity to certain components may occur. The most common symptoms associated with the use of GLP-1 receptor agonists are gastrointestinal symptoms, mainly nausea, bloating, or diarrhea. If in doubt, consult your healthcare professional.

What safety precautions should be observed while taking a GLP-1 OPTIMAL?

WARNING

  • For adults only. Do not take on an empty stomach.
  • Not for use by pregnant or nursing women.
  • Not recommended for individuals with diabetes, liver or heart conditions, known allergies, or those taking medications.
  • Keep out of reach of children.
  • Store in a cool, dry place, away from heat, moisture, and light.

What supplements should you avoid while taking GLP-1 OPTIMAL?

You should avoid taking other weight-loss supplements alongside GLP-1 OPTIMAL without medical advice. This includes : 
•        Blood sugar–lowering supplements which can additive-lower blood sugar and increase the risk of hypoglycemia, especially if combined with other diabetes medications.
•        Stimulant or appetite-suppressant supplements. GLP-1 OPTIMAL already reduce appetite, stacking stimulants can cause nausea, heart palpitations, or excess weight loss.
•        Supplements that may irritate the gut. Because GLP-1 OPTIMAL can cause nausea, bloating, or diarrhea, avoid gut-irritating products, especially at high doses.

Can I take multiple Wellio products together?

Yes! We recommend combining GLP-1 Optimal or Akkermansia Support with our Fiber Gummy for enhanced gut and metabolic health. They’re designed to work synergistically.

Can I take GLP-1 OPTIMAL with other medications?

If you are undergoing medical treatment or have a health condition, consult your healthcare professional before adding a supplement like GLP-1 OPTIMAL to your routine.

Are there any medications you shouldn’t take this with or while on GLP-1 OPTIMAL ?

The biggest risks are with other diabetes medications, drugs that must be absorbed at a specific rate, or additional weight-loss agents. Always give your doctor or pharmacist a full list of prescriptions, supplements, and over-the-counters so they can check for interactions.
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal
GLP-1 Optimal

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